Pulsed Electromagnetic Fields and Tumor-Targeted Radiofrequencies in Cancer Therapy: A Review of Experimental and Clinical Evidence
Author : Hung V. Le, PhD Abstract Pulsed electromagnetic fields (PEMF) and amplitude-modulated radiofrequency electromagnetic fields (AM-RF EMF) are emerging as non-invasive adjuncts in cancer therapy. Initially approved for bone healing and pain management, PEMF has shown potential in inhibiting tumor cell proliferation, inducing apoptosis, and impairing angiogenesis in various preclinical models. This review synthesizes findings from studies involving low- and high-intensity PEMF, tumor-treating alternating electric fields, and tumor-specific AM-RF EMF across cancer cell lines, animal models, and early-phase human trials. While results are promising, therapeutic responses remain highly context-dependent and mechanistically heterogeneous. Advances in structural biology and cancer genomics offer new opportunities to rationally design field parameters targeting specific molecular pathways. We propose a framework for estimating the electromagnetic field strength needed to disrupt...